Polypropylene microplastics promote metastatic features in human breast cancer.
May 22, 2024 · [34].
Polypropylene microplastics promote metastatic features in human breast cancer. 聚丙烯微塑料促进人乳腺癌的转移特征 .
Polypropylene microplastics promote metastatic features in human breast cancer 2023;13:6252. Polypropylene microplastics promote metastatic features in human breast cancer. 1038/s41598-023-33393-8. However, to date, the effect of microplastics on skin cancer is not fully understood and is a scientific question that urgently needs to be addressed. responses of secondary polypropylene microplastics (PP Furthermore, in a study led by Jun Hyung Park, the potential role of polypropylene microplastics (PPMPs) in promoting breast cancer metastasis was explored. Metastasis is driven by extensive cooperation between a tumor and its microenvironment, resulting May 1, 2025 · Polypropylene microplastics promote metastatic features in human breast cancer. Microplastics, ubiquitous in the human body, often undergo an aging process due to long-term exposure to indoor and outdoor environmental conditions. Unfortunately, studies on fragment-type MPs are very limited and Polypropylene microplastics promote metastatic features in human breast cancer Scientific Reports ( IF 3. MPNPs pose significant health risks due to their mutagenic and May 8, 2025 · Polypropylene microplastics promote metastatic features in human breast cancer Article Open access 17 April 2023. 6252, 10. et al. Sci Rep. Shahsavaripour, M. Chen et al. Apr 17, 2023 · Polypropylene microplastics promote metastatic features in human breast cancer. promote metastatic features in human breast cancer. Microplastics in The widespread use of plastic has led to growing concerns about the release and impact of microplastics and nanoplastics (MPNPs) on both the environment and human health. The surge in plastic production during the COVID-19 pandemic increased the potential for human exposure through ingestion, inhalation, and dermal absorption. The same cell lines were used in the Dec 13, 2023 · Environmental hazard of polypropylene microplastics from disposable medical masks: acute toxicity towards Daphnia magna and current knowledge on other polypropylene microplastics, Microplastic and Nanoplastic, Jan. Recent studies have revealed an increased incidence of colorectal cancer among workers in the plastic and rubber industries, suggesting a potential link between occupational exposure to plastic-related compounds and cancer risk [30]. Proof of principle study: synchrotron X-ray fluorescence microscopy for May 1, 2021 · Metastasis of breast cancer and recurrence to incurable disease are leading causes of mortality. Apr 26, 2023 · Polypropylene microplastics promote metastatic features in human breast cancer: Organism: Homo sapiens: Experiment type: Expression profiling by high throughput sequencing: Summary: we studied the effect that 16. Objectives Although research on MPs has Aug 30, 2023 · Polypropylene microplastics promote metastatic features in human breast cancer . By exposing MDA-MB-231 breast cancer cells to PPMP concentrations of 1. Interestingly, recent studies have highlighted the impact of microplastics can on the prognosis of cancer patients. DOI: 10. Scientific Reports. Jan 22, 2025 · But one study did find that irregular-shaped polypropylene microplastics can affect human breast cancer cells by driving the cancer's progression. Polypropylene microplastics . Sci Rep 2023;13(1):6252. … Jul 27, 2024 · while microplastics promote proliferation in skin . Sep 20, 2024 · These findings suggest that microplastics may contribute to chronic disease development and pose significant health risks. The detrimental effects of PPMPs on breast cancer metastasis were examined. 13: 6252, 2023. Apr 17, 2023 · Microplastics (MPs) are now a global issue due to increased plastic production and use. This is one of the first studies to show how Mar 15, 2025 · Various studies have provided mounting evidence suggesting that MPs may contribute to the progression of various cancers, such as colorectal cancer, skin cancer, ovarian cancer, and breast cancer (Brynzak-Schreiber et al. Dec 1, 2024 · The human body constantly generates cells with the potential to become cancerous [28]. CAU Scholar's Space: Polypropylene microplastics promote metastatic features in human breast cancer Mentioning: 4 - Microplastics (MPs) are now a global issue due to increased plastic production and use. Recently, various studies have been performed in response to the human health risk assessment. These results suggest that PPMP enhances metastasis-related gene expression and cytokines in breast cancer cells, exacerbating breast cancer metastasis. Rep. MDA-MB-231 cancer cells were allowed to settle overnight in a 96-well at a density of 5 × 103 cells per well and were mixed with PPMPs, which were then sterilized by autoclaving (a process that uses pressurized steam to sterilize equipment, glassware, and other items) and mixed with the medium for eventual sonication. 4 µm fragment type polypropylene microplastics, which have an irregular shape and sharp edges and form naturally in the environment, had on breast cancer. Published in Scientific Reports ISSN 2045-2322 (Online) Publisher OPEN Polypropylene microplastics promote metastatic features in human breast cancer Jun Hyung Park 1,5, Seungwoo Hong 2,5, Ok‑Hyeon Kim 3, Chul‑Hong Kim 4, Jinho Kim 4, Jung‑Woong Kim 4*, Sungguan Hong 2* & Hyun Jung Lee 1,3* Microplastics (MPs) are now a global issue due to increased plastic production and use. H. “Human occupational exposure to microplastics: A cross-sectional study in a plastic products manufacturing plant. 1038/s41598-023-33393-8 这项研究的创新点在于，它着眼于碎片型微塑料的研究，这种类型的微塑料在自然界中占据了绝大多数。此外，该研究揭示了ppmp对乳腺癌转移的影响，这对于人们更好地了解微塑料对人类健康的影响具有重要意义。 Polypropylene microplastics promote metastatic features in human breast cancer Jun Hyung Park1,5, Seungwoo Hong2,5, Ok‑Hyeon Kim3, Chul‑Hong Kim4, Jinho Kim4, Jung‑Woong Kim4*, Sungguan Hong2* & Hyun Jung Lee1,3* Microplastics (MPs) are now a global issue due to increased plastic production and use. Recently, various studies have been performed in response to the Polypropylene microplastics promote metastatic features in human breast cancer Published in: Scientific Reports, April 2023 DOI: 10. 2023 ↩︎ Jan 1, 2025 · Microplastics (MPs) have been found in human breast cancer tissues for the first time. Apr 18, 2023 · In this study, we studied the effect that 16. ” Science of the Total we studied the effect that 16. 4 µm fragment type polypropylene (PP) MPs, which have an irregular shape and sharp edges and form naturally in the environment, had on breast cancer PPMP incubation for 24 hours in the MDA-MB-231 cells significantly altered the level of cell cycle-related transcripts in an RNA-seq analysis Nov 15, 2023 · Park et al. Unfortunately, studies on fragment-type MPs are Document is current Any future updates will be listed below. Mar 20, 2025 · MPs can accumulate or react at various sites of the body and cause major cancer risks including skin-cancer , breast-cancer , cervical-cancer , and colorectal-cancer , and also promote the risk of cancer including testicular cancer, Alzheimer’s disease and dementia at various stages in humans due to their daily lifestyle as the MPs are Polypropylene microplastics promote metastatic features in human breast cancer JH Park, S Hong, OH Kim, CH Kim, J Kim, JW Kim, S Hong, HJ Lee Scientific reports 13 (1), 6252 , 2023 Polypropylene microplastics promote metastatic features in human breast cancer . (2023) showed that microplastics could promote the metabolism of tumors. , 2023). [PMC free article] [Google Scholar] 7. However, these studies have focused on spherical MPs, which have smooth edges and a spherical shape and account for less than 1% of MPs in nature. For instance, PP microplastics have been implicated in the promotion of breast cancer metastasis [2]. 1038/s41598-023-33393-8 1. Polypropylene microplastics promote metastatic features in human breast cancer Scientific Reports ( IF 3. Therefore, it is necessary to further explore the Polypropylene microplastics promote metastatic features in human breast cancer - Scientific Reports nature. , 2023; Chen et al. (2023) reported that microplastics (nano-scaled) could accelerate the tumor growth in vivo. , 2024; Wang et al. . 10. May 1, 2025 · Among the various diseases that microplastics can induce in the human body, cancer stands out as one of the most fatal. Sci. Oct 30, 2024 · The absorption of nano- and microplastics derived from different polymers in a particle size- and dose-dependent manner has been demonstrated for several normal cell types and cancer cells, such as human mast cells (HMC-1), human dermal fibroblasts (HDFs), peripheral blood mononuclear cells, intestinal epithelial cells, CCD-18Co human Apr 17, 2023 · Microplastics (MPs) are now a global issue due to increased plastic production and use. Microplastics (MPs) are now a global issue due to increased plastic production and use. However, these studies have focused on spherical MPs, which have smooth edges and a spherical shape and account for Polypropylene microplastics promote metastatic features in human breast cancer Jun Hyung Park1,5, Seungwoo Hong2,5, Ok‑Hyeon Kim3, Chul‑Hong Kim4, Jinho Kim4, Jung‑Woong Kim4*, Sungguan Hong2* & Hyun Jung Lee1,3* Microplastics (MPs) are now a global issue due to increased plastic production and use. However, these studies have focused on spherical MPs, which have smooth edges and a spherical shape and account for May 2, 2023 · Park, J. Scientific Reports, Apr 2023 Park, Jun Hyung, Hong, Seungwoo, Kim, Ok Europe PMC is an archive of life sciences journal literature. 2022 ↩︎; Polypropylene microplastics promote metastatic features in human breast cancer, Scientific Reports, Apr. Sci Rep . , 13 (1) (2023), p. However, these studies have focused on spherical MPs, which have smooth edg Dec 1, 2024 · Additionally, research by Park et al. , 2024). Incubation Biochemistry Medicine Biology Cancer cell Cancer Internal medicine Cancer CAU Scholar's Space: Polypropylene microplastics promote metastatic features in human breast cancer Park JH, Hong S, Kim OH, Kim CH, Kim J, Kim JW, et al. MPs can enter cells via ANXA2 and further cause mitochondrial damage and mitophagy. “Polypropylene microplastics promote metastatic features in human breast cancer. ” Scientific Reports. (2023). The graph shows the survival rates of cells with or without Polypropylene microplastics promote metastatic features in human breast cancer Jun Hyung Park1,5, Seungwoo Hong2,5, Ok‑Hyeon Kim3, Chul‑Hong Kim4, Jinho Kim4, Further, secretion of the pro-inflammatory cytokine IL-6 from cancer cells was elevated with the incubation of PPMP for 12 hours. FIGURE 2A. Crossref DOI link: https Microplastics (MPs) are typically less than 5 mm in size and are not only derived from the degradation of plastic objects in the environment but are also produced for commercial uses 1,2 PMID- 37069244 OWN - NLM STAT- MEDLINE DCOM- 20230419 LR - 20230426 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 13 IP - 1 DP - 2023 Apr 17 TI - Polypropylene microplastics promote metastatic features in human breast cancer. , 2024a; Park et al. After binding to ANXA2, MPs can induce mitophagy by IL-17 signaling pathway. 4 µm fragment type polypropylene (PP) MPs, which have an irregular shape and sharp edges and form naturally in the environment, had May 2, 2023 · Researchers report plastic fragments may exacerbate breast cancer metastasis; review summarizes nanoplastic uptake into human cells; studies find occupational microplastics exposure can be reduced by wearing face masks; millions of micro- and nanoplastics are released during 30-second food blending; scientists more worried about microplastic impacts on the environment than humans Apr 17, 2023 · Effect of PPMP on cell viability in human breast cancer cells. Notably, the use of MPs markedly increased during and after the corona virus disease 2019 pandemic due to the heightened emphasis on personal hygiene and sanitation. Recently, Microplastics (MPs) are now a global issue due to increased plastic production and use. Polypropylene microplastics promote metastatic features in human breast cancer Organism: Homo sapiens (Taxonomy ID 9606) BioProject Accession: PRJNA907409 ID: 907409 In this study, we studied the effect that 16. of PPMPs on breast cancer metastasis were examined. Microplastics may potentially trigger increased cancer risks [13]. Alarmingly, accelerated tumor growth was observed in gastric cancer-bearing mice exposed to polystyrene microplastics, which also induced May 22, 2024 · [34]. demonstrated that polypropylene microplastics enhance metastasis-associated gene expression, further elucidating potential mechanisms of cancer progression [22]. 4µm fragment type polypropylene (PP) MPs, which have an irregular shape and sharp edges and form naturally in the environment, had on breast cancer. from publication: Polypropylene microplastics promote metastatic features in human breast cancer | Microplastics (MPs) are now a global issue promote metastatic features in human breast cancer Jun Hyung Park1,5, Seungwoo Hong2,5, Ok‑Hyeon Kim3, Chul‑Hong Kim4, Jinho Kim4, Jung‑Woong Kim4*, Sungguan Hong2* & Hyun Jung Lee1,3* Microplastics (MPs) are now a global issue due to increased plastic production and use. PubMed 由于塑料生产和使用的增加，微塑料 (MP) 现在已成为一个全球性问题。最近，针对人类健康风险评估进行了各种研究。然而，这些研究都集中在球形 MPs 上，它们具有光滑的边缘和球形，在自然界中占 MPs 的不到 1%。 Jan 1, 2024 · Polypropylene microplastics promote metastatic features in human breast cancer PPMPs on breast cancer metastasis were examined. (A) PPMPs were added to the MDA-MB-231 cells and incubated for 24 hours. Oct 1, 2024 · Polypropylene microplastics promote metastatic features in human breast cancer. com 8 Like Comment Share Copy; LinkedIn; Facebook; Twitter; To view or add a Jun Hyung Park's 3 research works with 3 citations and 59 reads, including: Polypropylene microplastics promote metastatic features in human breast cancer Jan 28, 2025 · Additionally, studies have shown that polypropylene microplastics enhance metastatic features in breast cancer cells by altering gene expression related to cell cycle regulation. However, these studies have focused on spherical MPs, which have smooth edges and a spherical shape and account for l … Park JH, Hong S, Kim OH, et al. May 26, 2025 · Background Microplastics (MP; particles < 5 mm) have emerged as contaminants of growing ecotoxicological concern in aquatic environments and are a potential threat to human health. Help using Europe PMC; Feb 1, 2025 · One of the most critical health risks associated with microplastics is their potential role as carcinogenic agents (Goswami et al. 8) Pub Date : 2023-04-17, DOI: 10. 4 µm fragment type polypropylene (PP) MPs, which have an irregular shape and sharp edges and form naturally in the environment, had on breast cancer. Recently, Apr 20, 2023 · [Scientific Reports] Scientists studied the effect that 16. Apr 17, 2023 · Polypropylene microplastics promote metastatic features in human breast cancer. 1038/s41598-023-33393-8: Pubmed ID: Dec 7, 2024 · Effect of PPMP on cell viability in human breast cancer cells. In fact, MPs can enter the body through inhalation, ingestion, and dermal absorption, they accumulate in various organs, such as the gastrointestinal tract, lungs, and bloodstream, and have been detected in stool, placenta, and even heart tissue, and induce The red arrows indicate a PPMP on the cell surface. Microplastics have also been reported to induce chronic inflammation and, when accumulated in neoplastic cells, may act as catalysts for cell proliferation and migration, contributing to cancer metastasis [10, 11]. 6 mg/mL for 24 h, the researchers uncovered a concerning link between PPMP exposure and the upregulation of metastasis Microplastics (MPs) are now a global issue due to increased plastic production and use. risk of ingested PAHs enriched microplastics by human beings (2023) Park et al. Jun Hyung Park 1 na1, Seungwoo Hong 2 na1, Ok-Hyeon Kim 3, Chul-Hong Kim 4, Jinho Kim 4, Jung-Woong Kim 4, Sungguan Apr 17, 2023 · Microplastics (MPs) are now a global issue due to increased plastic production and use. Data from Park and colleagues revealed that polypropylene (PP) microplastics likely promote metastatic features in human MDA-MB-231 and MCF-7 breast cancer cells by increasing metastasis-related gene expression [15]. 聚丙烯微塑料促进人乳腺癌的转移特征 May 4, 2025 · Although human epidemiological data are still emerging, the mechanistic evidence from recent studies highlights the potential for microplastics to cause long-term adverse health effects through persistent accumulation and vascular obstruction. lkhnwovuxpwjvtvzbfjxcvyrywkpucjusjcqpbipefwbiprqdwpwne