Too much methylfolate reddit.
Too much methylfolate reddit Tons of vegetarian stuff is supplemented with folic acid. I curl my hair with heatless curlers as well to give some volume. I have a hard time tolerating methylfolate. In medical literature, however, demyelination and other B12 deficiency symptoms have been recorded as people with borderline B12 status who corrected their folate deficiencies found that their low B12 stores were rapidly used. I haven't been on it long enough to see results, but I've been chronically vitamin deficient (mostly b12, d3, and iron) pretty much my whole life. Like it was the key to what i was missing my whole life. Now that much would cause serious brain fog. I switched to methylfolate, which felt gentler to me (folinic acid and adenosyl hydroxo B12 felt like I was on too much). I was actually diagnosed with Graves’ disease while supplementing methylfolate and I kind of believe it precipitated my diagnosis. In general, minerals are tricky because there is no substitutes for them and one has to get the right amount (not too much and not too little). Early Feb I switched to methylfolate 1mg daily 11th March switched to 5mg methylfolate daily. It causes fatigue during the day, insomnia, and makes me have pain during a Bowel Movement, and then forces m to take a nap after BM for 1. I believe there are studies that back that up. Heart beating, tightness of chest etc. Creatine by itself helps but too much or taking it for more than a week straight causes some anxiety/irritability. It made my mind race to an uncomfortable point. I am homozygous C677TT and my doctor said between 1000 and 1600 mcg is a proper amount. I experienced the feeling of my head being in a microwave, and he electricity racing in my brain. but i need it regardless of anxiety otherwise fatigue digestive issues allergies and brain fog eat me alive. But I’m guessing too much of it without enough amounts of tryptophan or other serotonin precursors may keep the levels in your brain or body down. I THINK it may have something to do with rapid magnesium depletion. Again, my doc is not concerned. Doesn't seem like you're taking magnesium, which is a critical co-factor for thiamine. Started to feel some strange anxiety I’d never felt before. Be aware that the optimum amount of piracetam (& most nootropics) varies from person to person &, for each person, will vary over time. Undermethylated people will feel worse taking methylfolate in large doses after a while, since too much folate trap methyl and also act as a serotonin reuptake promoter. There is no reason for that much. NAC used to clear my fog, but now methylfolate seems to do the same and make NAC do pretty much nothing, so I suspect I really do have low methylation capacity at least as one of my problems, since low methylation would also probably mean low cysteine and glutathione (which NAC boosts). I stopped taking the methylfolate on Tuesday when I realised, but not much improvement yet. If not eaten from natural sources, the methyl folate can be taken to supplement the slower reactions. I am going to keep saying this over and over on this forum because it seriously was a game changer for me. One week was fine, then symptoms of methylfolate side effects occurred. It's definitely a thing & I'm pretty worried it's caused me a lot of problemsMethylfolate Side effects This means a) not enough ACTIVE folate (L-methylfolate) in the body and b) the body produces too much homocysteine, which is inflammatory in high amounts, to compensate. I've seen on this site that some doctors are prescribing niacin to slow the overmethylation, but don't know what dose or how often. Reply reply More replies Methylfolate cured my depression and is helping me handle chronic fatigue, but Im still figuring out the dosage. If you have too much serotonin reuptake happening, serontonin levels will be low. b complex My psychiatrist prescribed me L-methylfolate to help my anti depression meds do their job. I also started getting muscle twitches in my leg/knee which I read could be from electrolyte deficiency? I stopped the methylfolate on Monday and the side effects have gotten better. Also anxiety and bodily feelings of nervousness went drastically down to a normal level. However, rare side effects include allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the 400 mcg methylfolate 500 mcg methylcobalamin I used to take 1,600 mcg methylfolate but found 400 mcg is just as effective. I originally took 2 daily. I began with 1mg, then 2mg the following day which was too much for me. The MTHFR protocol above is intended to use that incremental approach. My doctor asked me to stop the supplement asap. I don’t know if I can cut the tablet much smaller so if I end up trying again in the future I will only do a few days per week maybe. The COMT being one of the drives of not tolerating. Too high acetylcholine primarily operates by inhibiting other neurotransmitters. He's now running more tests. Supplementation of B12 for a number of weeks prior to supplementing methylfolate, will avoid reactions to methylfolate. So I cut back to 400mcg (splitting pills, which I dislike) for a month and had my labs drawn again. I take methylfolate in addition to my Thorne basic Prenatal which also has (a smaller amount of) methylfolate in it. COMT mutations are the ones that make you mentally ill (together with MAO) because of the slow (COMT) reuptake of neurotransmitters. Taking niacin calmed it right away. Then yesterday I heard a JRE podcast about how the US sprays everything with Folic Acid unless it's organic and supposedly 40+% of people can't process it and it's poisoning them. I prefer liquid methylfolate (100mcg per drop) as you can change your daily dose easily, and liquid versions typically don’t have irritating fillers, cellulose etc. I agree. Its strange. But methylfolate is better absorbed, people with common MTHFR mutations can't utilize folic acid well, and the more folic acid they have, the worse issues it can I have fast COMT (val/val) and I'm curious about what supplements you guys take and which you guys actively avoid. Started with 1000mg. Methylfolate is also required for serotonin production somehow. Its deficiency can lead to anemia and birth defects during pregnancy. Sometimes it feels like I'm taking too much- I can't explain why, it's just an off feeling. A few days afterwards, I reduced my Methylfolate to 400mcg, and that has been working much better - still having the mental clarity/lucidity without the brain fog. Now that I stopped the Sam-e, my MMA is slowly coming down… but as homocysteine gets recycled into methionine (if there is adequate methylfolate and methyl B12 or the minor pathway of betaine)…. I’ve tried methylfolate with p5p and methyl b12 and it doesn’t help much. Less is more, you can over do methylation and it's not a fun feeling. If I take too much methylfolate or methylB12 then I can be sort of hyper and on edge which is not pleasant. (Since it made no difference in that regard, even after four months). The subject is simply too complex and variable. ) It’s best to get in diet only but you can check levels Dec 16, 2024 · Today I tried a B complex tablet and I honestly feel absolutely horrendous, so anxious, wired and feeling mentally not good. Surely you'd still need to supplement with folate/Folinic acid/MethylFolin (not Methylfolate) alongside Choline if you're Methylation is impaired. im gonna try 50 mg nicotinic acid as a fix because im sensitive to methyl donnors cause of ComT, so that might be the issue. Get the Reddit app Scan this QR code to download the app now Seems like a lot of B6 too. interesting, I was confirmed recently to have the MTHFR gene and I started taking L-Methylfolate. Overmethylation is thought to occur when the body has more methyl groups than it needs or can use. I would also take at least one week off of folate before checking, to make sure any folate supplements are out of your system. Methyl folate is the best version of folate. In my opinion, Any amount of folic acid is way too much if you have access to L-5-Methyltetrahydrofolate… especially if you have a MTHFR mutation. I wouldn't be surprised if I had a folate deficiency as I had some issues with my red blood cells being too large a while ago which can be related - I have since fixed this. I'm a 42 yo man living in Russia. I've had better luck with 50-100 nicotinic acid (flush) Some of his articles have been retracted, which is never a good sign. I would try to gauge your intake from food and or supplements. He started me on a low dose of Sam-e (200mg) every morning for 4 weeks, then increased to 400mg. Worst case scenario if I use too much I feel tired and kind of depressed which I much prefer to the horrendous overwhelming anxiety and overstimulation caused by methyl folate. Any concerns for taking this much B12 daily? I would like to take 2 tablets per day after starting to get more folate, but that seems like a super high Ken, it’s because neurotransmitters require folate to function. According to my doctor (functional medicine) slow comt means you are not producing much Sam-e. It may be worth looking into tape extensions as an option to add volume too, I just can’t afford the upkeep myself. I was using 15mcg of the MTHFR, per my MD's orders, and it was too much. Cut way back down to under 1mg and see how Folic acid undergoes a very slow conversion to folate via enzymes, and having too much folic acid in your body isn't exactly a good thing. B12 uses up potassium when making new cells on your body. Too much imo but some people take grams, either way you need to take it for a while to get effects. Do Not Suggest Prescription Drugs Posts & Comments Reported as: Do Not Suggest Prescription Drugs Prescription drugs are not Supplements; do not recommend prescription medication. You are supposed to avoid all folic acid on methylfolate, by the way, as it blocks uptake. 2nd question is how does overmethylation cause anger, irritability, and sometimes intense internal rage? I notice myself sometimes over reacting when over methylated. You don't need to go that high. For injectable methylb12**, if it is exposed to too much light (very little light actually is too much) it breaks down. I believe that there are sensitive people who can get too much methylfolate with just a little. It’s very possible. I tried taking L-methylfolate at a dose of 15 mg day. Some people do okay and then Boom- it’s too much and they are symptomatic for months due to the Folic acid is synthetic pro-folate and methylfolate is a converted or activated form of folate. or any folate other than in meals. Been on and off methylfolate 15mg (currently on after recent testing found my homocysteine to be 120). Usually not more than 50mcg is recommended in this case to make sure you use it all. Too much nonmethylated B12 causes insomnia for me. On this day--with no injection--I took in 3200mcg methylfolate and 4100mcg B12 (methyl and adeno, but not injected). My BP seems to be unaffected by this new supplement (consistently 117/77) so I’m keen to keep taking them. Can easily become negative if I take too much, especially with creatine Creatine ~4 g daily, 1 g at a time Speeds up my thinking and gives me mental energy an resilience Gives me physical endurance Used to take less, but 4 g helps keep my levels up better and I can tolerate if if I don't take 5-MTHF too much From 5 days on 400mcg of methylfolate I got some back spasms and all around joint sensitivities. I can't imagine how many people start a multivitamin with methylfolate in it and after a while develop mental health issues because of it, but aren't able to understand that methylfolate is causing this and they just keep taking it. The symptoms of too high acetylcholine may be similar to the symptoms of too low serotonin, as they have a close balancing relationship Depression has been linked with higher acetylcholine activity in certain brain areas So 400mcg is great for 2 days then becomes too much. Mar 1, 2012 · I took them before bedtime. Also at least 300-600 mg magnesium which is needed to absorb the b vitamins in such high doses, a deficiency also leads to massive anxiety, fatigue, muscle pain. I'm shocked and impressed that your doctor recommended methylfolate. The study of Methylation and it's effects on the brain is still incomplete, particularlly when it comes to treatment. My psychiatrist gave me 2 weeks of Deplin samples. Also do not use methylfolate or methylB12. Reduced it to 400mcg and felt much better after a couple of days. Then tried supplementing just folinic acid as it didn't seem to exacerbate symptoms like other Bs but improved energy, mood etc. Creatine can help you conserve methylfolate so it's helpful but you're going to deplete glycine significantly more with the "hypo" MTHFR variant either way. Broken down methylb12 is hydroxyb12. 2. Yet as far as focusing on tasks or bettering myself has been, not much has changed. Now, TMG capsules I have make me feel horrible, even at low 500mg doses. would watch out for neurotoxicity. Hey guys, I’m double homozygous for MTHFR C677T. I… Heard about methyl folate and decided to try it out since it wasn’t too expensive online (Now brand, Amazon). If you added-on more in supplement form, then added 5-MTHF in addition… I would expect that to have a negative effect. Hey guys, So I took 400mcg of Methylfolate and been experiencing some intense anxiety now a few hours after. ** Broken down methylb12 is hydroxyb12. Most people consume too much folate (regardless of methylation status. I'm a 27-year-old girl, earlier this year I did a blood test and saw I have relatively low folic acid - 3. com Jun 9, 2017 · It depends if you have symptoms with it. View community ranking In the Top 1% of largest communities on Reddit Methyl B12 is Dangerous for some people! The reason why Methyl B12 is causing these strange effects (anxiety, feeling of doom, shortness of breath, palpitations and high blood pressure) is plain and simple. It's nearly impossible to overdose as it is water soluble. Could I be removing too much homocysteine and lowering my methionine that is needed to create Sam-e by taking NAC and MSM? My psychiatrist prescribed me 7. I've also had to tweak my methylfolate and methylB12 dosages I've dropped to 100mcg of methylfolate and 325 mcg of methylB12. At my next appointment, I have a feeling he'll increase my dose again. Methylfolate is the active form of folate and uses up B12 to perform critical functions. From these threads I've heard success stories with folinic acid, did you have a recommended brand? I'm not sure about IH niacin as that's sold at 500mg which is too much. Yup, I was. The slow COMT that you have will likely make methyls not tolerable for you. Yes, it is possible. Still couldn't increase my B12 dose, so I figured I was still high. Your body needs to recalibrate this complex network of chemical interactions to changing methylation, so starting with low doses and working up incrementally over time can prevent/minimize those side effects. I think it might've been too much folate for me as it made me irritable, gassy, and tired. Some of the sublinguals had methylfolate in them too. It has worked well for me, whereas methyl folate & b12 are too much. Then continue as long as you want, or cycle after 2 months. Some people start with SAM-e and transition to Methionine. I would not put much stock in what someone else is doing bc it’s so bio individualized. Can I just say that coming across this post made me smile, I’ve started a strong multivitamin b supplement and noticed a change in this regard too. I still grind teeth in the night, and have a tense posture but this doesn't bother me too much. Late to the party. true. P5P is the best one. I haven't tested for MTHFR mutation, but my mum is prescribed methylfolate and I can only assume that she suffers the genetic mutation. The B Right brand has too much B6 and you run the risk of toxicity. Can I go from undermethylation to overmethylation with too much methylb12 and methylfolate? Question I learned about methylation a few years back, took the 23andme test like many of you, discussed the results with my doctor, and began supplementing methylb12 (1000-2000mcg) and methylb12 (400-800mcg) daily. A significant proportion of the population (at least 20% of all people) have a very common genetic variation (MTHFR) that makes them unable to absorb folic acid; worse yet, it can block their absorption of actual folate present in the foods that they eat, which can contribute to fatigue Dear friends, this post is my attempt to clarify the topic of semen retention, clear misconceptions and debunk the myths around it. 4-2mg depending on age, and if you’re actually deficient. It doesn't bother me too much that he is a chemical engineer, although it seems a little unusual for someone making "health discoveries," but he seems a little too interested in self-help and self-promotion to be taken at his word. I did not get the jitters when I went slowly. Much of this forms a buffer in your bloodstream where methyl groups can be taken back (not clear what enzyme does this btw), but your kidneys will also pee out some of this. MTHFR mutations usually pulls the balance towards undermethylation, but there are several other mutations affecting balance, so overmethylation is quite possible. I was prescribed 15mg for depression, but it makes me very very anxious and I don't want to use methylfolate as a treatment for depression necessarily, just for the MTHFR illness. If someone can’t process much folic acid, they need other forms of folate. Oh for sure. When i first started taking the methyl donors like methylfolate methylcobalamin and TMG, i felt amazing. Maybe I missed that section but what I got from that article is that just consuming folic acid causes a state where the mice have reduced methylation capacity and reduce methylTHF. L-methylfolate too much I'm on a pretty high dose (15) of l-methylfolate. So many people have the mthfr mutation, but other factors can reduce our natural ability to convert folic acid to l-methylfolate. 5mg a day and noticed my Adderall started feeling waaaay too strong each day, and I was feeling more and more alert and mentally sharp when my Adderall would normally be totally worn off. Because you are supplying these directly, you may potentially provide too little or too many, so it may be a bit tricky. “It’s just a supplement, surely it won’t have any side effects/etc” WRONG lol Theoretically yes too much folate can deplete b12 and 5mg is a huge amount. You're psyching yourself up. A genesite test showed I had one inactive allele that would code for producing L-methylfolate from folate or folic acid. ** It doesn’t work at healing brain/cord problems of those who have a presumed low CSF cobalamin level. I feel that way if I take an 800mcg folinic. I was emotionally severly disregulated, and patience low and irritability was super high. So I was on 5mg daily for 1 month & have not been taking any for a week. I don’t respond too well with any of these, maybe except betaine. At first I didn't feel any changes, so I kept taking it. That’s actually a really high dose. 21M, Hi guys I´m 4+ months on b12 injections (hydro) and i recently switched from 1mg methylfolate to 15 mg methylfolate, with the 1 mg i had only… Alcohol inhibits vitamin B1 absorption and caffeine inhibits vitamin b6 absorption so diet matters on how much you need. The underlying cause of your anxiety is the way you handle your emotions by not being free to express them, particularly anger and sadness. I get super irritable and anxious, my foot cramps too - but this is WITH taking tons of magnesium alongside methylfolate. 4 nmol/L and my B12 levels were 177 pmol/L. It’s only my second time trying the folinic so yes now I am sure that it is the culprit and it hits me hard pretty fast. I just now realized each tablet contains 5,000 mcg of methyl B12… some 200,000% of the RDA. Daily user here. That much is going to through your kidneys as waste and may overwork them. Folinic acid is active, just like methylfolate, but doesn't seem to have the strong negative side-effects that methylfolate might have. In fact, approximately 80% of the folate in your blood is methylfolate, not folic acid—folic acid is often found in supplements and fortified foods, but it’s not bioavailable and is harder to metabolize. Very blah. Likely, but not definitely. L-5-MTHF (L-methylfolate) B12 (cobalamin) Methionine Homocysteine Folic acid Here is the goal: We want healthy serum levels of L-methylfolate, B12 and methionine (not too much, not too little) We want as little serum homocysteine as possible (it should have already moved on in the cycle), but not too low. Folic acid is the cheap, synthetic form of the nutrient folate, AKA vitamin B9. Taking L-methylfolate specifically as a supplement (lifeway L-methylfolate is good for OTC), not just eating folate in food, solves that problem if you have that version of the I'm homozygous for C677T and wanted to know how much should I take to satisfy my body needs. Nov 21, 2023 · 5mg of methylfolate is a very high dose and likely causes side effects. Dec 16, 2024 · Rules of r/supplements. L-methylfolate allows us to synthesize neurotransmitters. It just felt real nice” [4] As for methylfolate, that is the form produced by the MTHFR enzyme, so supplementing it will bypass the chain of enzymes that go from food folate to MTHFR, and supply methyl groups to the SAM cycle. 5 hours. Much easier to manage, can do loads of fun styles still and looks thicker. Anyone know why this is? Also if I am low in folate - why would folic acid + Methylfolate make me feel bad? Want to add to the discussion? Mar 1, 2012 · Those who have MTHFR mutations (especially the C677T MTHFR mutation) learn that methylfolate is critical to take – and that folic acid is critical to avoid. The dose of methylfolate is selected individually by gradually increasing the dosage, no one knows how much you personally may need. WOW…night and day difference compared to where I was before. Whenever I take higher doses of methylfolate/B12 I feel overmethylated and either feel down or anxious, but TMG and NAC do not seem to have the same effect (at least not as much). Definitely going to try eating more, plus things with a good supply of iron and folic acid and trying to stick out with the tablets for the time being. My doctor is pleased since the recommended dose for women should not exceed 350mg. I’ve been taking l-methylfolate for about 3 years at 15mg because I was told I have the MTHFR gene. Too much puts you into overmethylation. Some symptoms I hadn't had in a few weeks came back: vibrating and tremoring muscles and waking up with dead numb hands. Abnormally Low Methylfolate Causes You to Piss Out Precious Methyl Groups! The take-home point about methylfolate, glycine and urine In my case, many supplements were "too much" and created anxiety and uncomfortable feelings. Red Blood Cell Production - Methylfolate helps your body produce red blood cells. "Another putative cause of vitamin B-12 deficiency is the high-folate–low vitamin B-12 interaction, first suspected as the cause for observed relapse and exacerbation of the neurological symptoms in patients with pernicious anemia who were prescribed high oral doses i have the exact same mutations as you and i respond to methylfolate the exact same way too. Stupor. It is my understanding that the body can only absorb so much at once. Most of those high doses are too strong for most ppl. This is why there has been no upper limit set for b12. However, I still feel some of the side effects of the 800mcg at a lower intensity (like dizziness, minor akathisia), so I think I will even try decreasing to 200mcg for a while. Methionine works every bit as well, it just takes a a few weeks longer. In 2009 when I started piracetam, my sweet spot was 7 g. I feel lucky I actually know about these effects of methylfolate. Felt great at first but it became too much. Too much folate can be just as harmful as not enough, so I encourage you to have your blood taken to check. Symptoms include weird neuro stuff (migraines, tremors, weakness, memory issues, pain, hyperreflexia…been evaluated for MS several times), chronic hives and food sensitivities, joint pain and swelling with severe Reynaud’s (suspected I don’t know exactly why. And I would take a high dose of a good b complex with 100 mg of all the b vitamins (except b6 and folate), at least 400 mcg methylfolate (add more methylfolate if needed) and 10-25 mg P5P. Feb 10, 2025 · Key Takeaways. Here's the thing: the two mutations commonly tested for are only 2 of something like 40 genes suspected to be involved in methylation so they're a horrifically incomplete picture of what may be going on. Posted by u/SquiddysInkies - 3 votes and 5 comments The methyl donor problem is usually one of too much too fast. I don’t know the biochemistry but many in another forum have discussed this problem. I read through parts of that first article and nowhere did it discuss that folic acid blocks the ability to absorb methylated folate. Apr 24, 2025 · Methylfolate performs a crucial role in the central nervous system, and an overdose is not likely to be life-threatening 4. So you might feel a little worse before it gets better if you don’t take care of your gut health. Methylfolate is essential for your overall wellbeing. use your words. too much If you have low folate, it's likely that you will experience good results from choline - one of the functions of folate is that it helps recycle homocysteine into much needed metabolites, choline is another pathway that does the same job, so if low on folate, the choline pathway may have been relied on for too long. It sounds like your doctor suspects you have a MTHFR polymorphism. Felt a slight but noticeable mood increase, pretty much the same feeling as I got with the B complex (Jarrow B-Right). B12 deficiancy is strongly correlated with depression, too. It’s as if the body must utilize all of it at once because it is in active form pushing the body to try to do too much at once. I take Codeage Methylfolate B complex. I have followed Dr. I have energy but feel so lackadaisical. Most people already get waaaay too much folic acid in their diet. Seems like it needs to be cycled. I now alternate days, and or reduce dose to . If I stop for a week then come back, I again get 2 great days, so that means I'm probably overmethylated after 3 days of 400mcg. Just from the 200 micrograms in a multivitamin. After a week I finally got too much. ) I've been able to reduce the dose of magnesium glycinate from 420 to 330mg. The symptoms for me have some very clear changes from the B12 deficiency/supplementation waves. Bought 6 bags of oat cereal (Purely Elizabeth, Organic Ancient Grain Granola) and I've felt fine after consuming way too much. He had me on 15mg a day and my anxiety increased 5 fold and I started having severe panic attacks thinking it was my Delta-8 THC. I took a prescribed b complex vitamin in addition to my prenatal while I was pregnant and had debilitating migraines 4x as often while I was pregnant and breastfeeding. After about 4 weeks of riboflavin 3x daily, my MAO A enzyme started working properly THEN I could go back and take B-complexes containing methylfolate like B-right and not be overstimulated. Currently, I am taking metb12 (to raise b12), methyl folate (i have homozygous c677T), and iron to raise my low ferritin levels. When you’re eating poorly and under stress, your gut has more gram negative bacteria, like e. AIP tends toward deficiency in calcium, magnesium, manganese, molybdenum, lithium, and silicon. 1mg of methylfolate is a pretty hefty dose if there's not enough active B12 in the body to support it. Aug 16, 2024 · L-Methylfolate is a remarkable folate supplement. You can overmethylate all too easily. The correct approach and the "solid science" approach is to try and establish how to clearly and properly test if methylfolate would be appropriate or not. And as a result, I feel like I've actually seen the effects of this. Hello everyone, I'm seeking advice because I'm not sure where to turn with this, but I've been supplementing for 2 weeks with 400mcg of methylfolate and 50 mcg vitamin B12 (cyanocobalamine) since my folate levels were low at 5. Now I feel similarly to how you describe. Do you have MTHFR? 10mg is ridiculously high to start off with, especially without b12. (1) Our guide to folic acid, folate, and methylfolate sheds more light on why you shouldn’t take folic acid and take bioavailable folate There are some people that say even taking too much Methylfolate/Folate in general and even just B12 can cause some issues involving Methylation, don't know too much about that but would make sense, you wouldn't find such high doses of these nutrients in nature anyway Even 100 mcg is too much! Yeah, I could take only methylfolate, but my research indicates it needs to be balanced with other B vitamins. Too many methyl groups may upset the proper function of the body’s normal biochemical processes, which may lead to symptoms like anxiety, fatigue, poor concentration, panic attacks, sleep disorders, and sensitivities to environmental toxins. e. Most people take 800-1600mg 2-3 times a day for 2-3 weeks before they get effects. 3 ng/ml. Aug 31, 2023 · When a person is regularly consuming too much alcohol for their body type, there are multiple reasons their folate levels drop, even on the same diet. Most methyl folate supplements are 400 mcg or some 800 mcg. Folate from food; methylfolate or folinic acid WARNING - See Phase 6 details: starting with too high of a dose of methylfolate can cause side effects!! Start low, go slow. I am now 7. If you’re feeling panicky, anxiety etc then that much methyl folate is too much for you. b2, b6, methylfolate (don't take too much, or too often), methylcobalamin, zinc, copper, magnesium, coq10, choline supplements (or food, like eggs), vitamin c at first it's normal to feel a bit speedy, if it persists reduce your methylfolate doseage plus an assortment of mast cell stabilizers Never worry about too much b12. You better believe I don't miss my daily dose. 73 votes, 47 comments. But many people give up before it has a chance to work. The methyl/folate ratio has a powerful impact on gene expression of reuptake transport proteins (page 13). More energy but no anxiety. I have other confounding factors like dysfunctional childhood and cocaine addiction but I believe MTHFR is the primary reason I had ADHD. 5 nd it's still too much. COMT going on overdrive because of MTHF could be an easy way to explain it, but at this point that's just a mere guess. I just recently was prescribed folic acid (though I requested methylfolate bc MTHFR) and quickly realized it triggers migraines for me. 1. But as you know, certain doses of MTHF can be stimulating too. My diet being bad in the last year or so is actually just not eating enough food, not too much. I asked how long it will take to drop my level back to normal but he had no answer. Recently learned I have a mutated MTHFR gene and for starters WOW. I, personally think it should be recommended for every woman. Now Im trying to increase the dosage slowly and have been having good results. I actually find Folin-ic acid to be much more stable than methyfolate. I rarely need melatonin now. But when I added methyl folate, too much made me jittery like I had too much coffee, maybe a little spacey too. First, studies show that when a person abuses alcohol, significantly less folate is absorbed from food through the small intestine [1]. Anxiety and depression. Taking some niacinamide will reduce this in around an hour or so. Thanks for the advice though. I was able to increase my B12 to 100mcg. Those who have MTHFR mutations (especially the C677T MTHFR mutation) learn that methylfolate is critical to take. I was only doing 100 micrograms for a few days so for me apparently that is too much. It was uncomfortable but no other problems. I'll send you a few links and you can decide which seems best for you. I got genetic testing done, found out I have a folate deficiency and an inability to process folic acid, began supplementing with methyl folate, and my symptoms are like 80% better on a daily basis and my only side effect is a little acne on my back when I take too much folate by accident. Maintenance Fine-tuning -as needed- I'm surprised then you don't mention a methyl B12, given mega dose would exacerbate such issues too. This has happened to me. Remember, too, that just because you have a mutation doesn't mean it's active. Also, taking too much can make you feel worse. 5mg methylfolate at the end of last month. Try cutting down the dose on the methyl folate & that should help. As others have said you may just have to push through this period, but TMG and NAC can help lower homocysteine levels, too. You will likely be low in potassium making you feel on edge. Methylfolate creates a weird agitation in me after a certain dose. I have an appointment with an Integrative Medicine specialist in May, but it would be nice to find a supplement before then! Eat healthy and take probiotics. coli, and if you don’t decrease their populationwell, they like l-methylfolate too. We would like to show you a description here but the site won’t allow us. Could it be too much dopamine lowering serotonin? Maybe just too much dopamine? Or maybe am i missing a certain nutrient, ie low homocysteine causing a methyl block? Idk We would like to show you a description here but the site won’t allow us. I stayed for a week on each dose to adjust to it before moving up. It's also best when coupled with b vitamins. Nov 25, 2014 · Methylfolate is a remarkable nutrient yet it can create significant side effects. I’ll try not to get into a big rant here on that and get to the point. Potassium tends to help a lot with methylfolate too, if you haven't tried it already. UPDATE December 7, View Article I’m not a good benchmark for you as I’m chronically low. One mistake I made with AIP was not getting enough calcium and magnesium which caused poor sleep. I didn't want to take the prescription folic acid (5 grams) because it felt like too much, so I took 800 mcg for 2-3 months. Realised folate is needed to use b12 in your body so makes sense that low folate resulted in high b12 considering my diet (always thought you couldn't get too much, as your body will just pee out whatever it doesn't I've registered on Reddit to post an answer. I realised on April 11th so stopped taking methylfolate. I used to tolerate high doses of betaine anhydrous powder. This makes SO MUCH SENSE. 5mg depending on if I'm eating foods that contain methylfolate that day. That IS insanely high. This can cause “methyl trapping”, where the excess methylfolate is unable to be utilised in the methionine cycle (through the MTR enzyme) as usable B12 levels are too low. My mental health has been in a terrible state for a while, maybe longer than i’ve been on this, but is it possible I could have overmethylated? See full list on mygenefood. I am homozygous C677T. Yeah this does warrant some thinking. Because SAM-e and Methionine raise Homocysteine, it's important to only have the dose you need. Methionine is easy on the gut and much less expensive. Lots of potassium used up in the start-up symptoms for both methylfolate and B12. (Yes, you can have too much serotonin in your body and some people do. Meanwhile, some people start right at 15mg, and barely have any side effects at all. Folate and B12 mentioned below, are not more important than other It's almost like someone else wrote this particular article. Many sources I found recommended beginning with 15mg which is way too high IMO. Ben Lynch’s protocol, taking many precursors in order to prepare myself to tolerate methylfolate. I also have slow comt and I use a Sam-e/tmg combo by xymogen. There are some health concerns, with stuff like cancer. As other, much more outspoken subreddits have said: "You can yell at the shit all you want, but don't touch it" i. Clarity and energy. Low is fine and then you can build up if you think you need to. These used to be my biggest problems. Glycine makes me feel awful no matter what One gene methyl turns off is the serotonin reuptake gene. I’m aware it’s water soluble, but this brand has too much B6 (35mg), Thorne has the same ingredients but less B6 (10mg), you may even want to find less than that as the DV is ~1. I ordered a Jarrow version of methylfolate, (800mcg) that has B6 and B12 in addition to the folate. Folate or folic acid appears to turn this gene on. I was also going to question this. I took a less expensive low dose methylated supplement for about 6 years. You mention being vegetarian. I was thinking I should catch up on lost B9. I’m hetero C677T and a1298c. Too much folate at once and or in a day can be the problem and result in the symptom you described. The issue is methylfolate can cause more harm than good if not started at the right time or tapered up slowly in amount. If you have too little, serotonin will be too high. Too much of the cheap vitamin b6 causes you not to absorb it. I have tons more energy and focus, and feel much better overall. Or else you'd be relying on Choline pathway too much and that surely has a detrimental effect? If you’ve noticed your longstanding symptoms getting worse over time and been attributing it to aging / pandemic brain / life: worth mentioning at your next annual physical to have your primary care provider rule out pernicious anemia as a contributing factor (an autoimmune disease that prevents your stomach from absorbing vitamin B12). All the oldschool research was done with folic acid, so the claims are for folic acid. I had read about L-methylfolate being helpful in some cases of depression as an add-on to antidepressants, so I tried just that. Well, too much active methylfolate is going to present problems just as hypo methylation would, so supplementing it is sort of like shooting at an apple on your buddy's head. Methylfolate Side Effects. Prior to this, I had been taking escitalopram 10 mg for depression for 2 years. It's too much methylfolate Before Methylfolate, i was coping with my symptoms using supplements and diet, including 10 eggs a day, creatine, non methylated b complex, and much more, everything was absolutely perfect UNTIL The day i tried methylfolate, One SINGLE dose of 200mcg my life literally went south, Aug 10, 2021 · The pharmaceutical companies recently got really interested in the MTHFR gene (which codes for the actual enzyme) because when it has a variation, you don’t efficiently pass the methyl group around, effectively leaving you with too much homocysteine, potentially increasing your chances of cardiovascular disease. If you choose to try it use a very small amount and slowly increase from there to gauge how it goes. I wouldn't put too much stock into poorly/un defined medical terms like under- and over-methylation. Odd mood reaction to too much methylfolate, has anyone had this and can explain it? Background: I am heterozygous C677T and A1298C, have a few other heterozygous mutations (DHFR, MTR, MTRR), homozygous mutations in 2 COMT genes, have obstructive sleep apnea, ADHD, and have been struggling with depression and anxiety. Now I take one on Monday Wednesday and Fridays. Anxiety meds really messed me up, I’d avoid those if you can. . Despite being an amazing vitamin, methylfolate can cause considerable side effects. Go to a regular MD and get a second opinion. It feels really liberating. 5 mg is a lot for the average person, although for some types of depression that are resistant to antidepressant treatment, up to 16 mg of methylfolate is prescribed or more. Works best for me that way. In clinical trials of Deplin, which is prescription methylfolate, there were no significant side effects recorded. When I forget to take it, I feel like crap. It's too bad that the hype of MTHFR doesn't include info about COMT. I have also experienced this before not as strongly when I tried 5mg Folic acid. I wonder if its too low homocysteine or overmethylation. I was recommended to start taking 15mg of l-methylfolate a day. I’ve taken it along with betaine/TMG (choline), glycine, and creatine. I had pretty bad effects with 800mcg methylfolate. Worked my way up to 7. Ever since initiating the methylfolate, I've had a major, life changing difference with my mental health and just how I think, regulate mood, my self talk, etc. Using methylfolate if you are overmethylated (produce too much SAM-e) and thus too much serotonin will have a diametrically different effect than for undermethylators. I still wouldn't be surprised if 15 mg is simply too much and hence the depressive effects, at least for some people. 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