Multidrug resistant serratia marcescens Here we report the draft genome sequence of the first KPC-2 and SRT-2 co-producing S. marcescens infection at an NICU. marcescens biogroup 1, Serratia liquefaciens, Serratia rubidaea, and Serratia odoriferous biogroups 1 and 2) are motile, slow lactose fermenters that are DNAse- and orthonitrophenyl galactoside (ONPG)– positive. 13:960285. 6 Indeed, lines of studies revealed an alarming Jun 29, 2022 · Here, we demonstrate that the production of prodigiosin by newly isolated S. Carroll, Trish M. 3389/fmicb. To investigate the antibacterial activity of Cinnamomum cassia L. marcescens associated with bloodstream infections in hospitals across the United Kingdom and Ireland between 2001 and 2011. Acquisition of multidrug-resistant Serratia marcescens by critically ill patients who consumed tap water during receipt of oral medication. 2016. marcescens strains involved in outbreaks are often multi-drug resistant, with intrinsic as well as acquired resistance . Transplantation Proceedings, 2007. High levels of antibiotic resistance across Serratia species are a consequence of the Purpose: The opportunistic multi-drug resistant nosocomial gram negative bacilli Serratia marcescens (S. In Serratia marcescens, class A group carbapenemases including SME and KPC May 4, 2023 · Antibiotic therapy is the main method of treating infections caused by S. Aug 3, 2018 · S. Robert A Equi MD, W. , J Clin Microbiol 54:120-126). Richard Green MD, in Survey of Ophthalmology, 2001. marcescens is associated with respiratory tract infections, Jun 28, 2022 · This bacteria remains somewhat of a mystery, and decisions about the treatment of S. Strain Db11, a kind gift from Dominique Ferrandon, is a spontaneous streptomycin-resistant derivative of strain Db10 which was isolated from a moribund Drosophila melanogaster in Sweden (Flyg et al. Notably, infections caused by multidrug-resistant S. 27(7):774-7. Serratia marcescens, a Gram-negative bacillus that belongs to the family Enterobacteriaceae, is a human opportunistic pathogen bacterium that causes many diseases, such as urinary tract infections The present study aimed to further clarify the genetic mechanisms responsible for the antimicrobial resistance of Serratia marcescens (S. High levels of antibiotic resistance across Serratia species are a consequence of the combined activity of intrinsic, acquired, and adaptive resistance elements. marcescens Sm39, respectively, and copper resistance genes in plasmid pCAV1492-199 also from strain S. marcescens, and describe isolates recovered from clinical settings are frequently described as multidrug resistant. Thirty-four patients had primary infections; four had cross-infections. 3%), while unique or exclusive genes -present in a single genome- were 8467 (43. May 17, 2013 · This outbreak was extremely difficult to terminate, even with cohorting of patients, sterilisation of equipment, reinforcement of handwashing and deep-cleaning of facilities, and the implementation of new control measures terminated the outbreak in February 2011. 1093/jac/dkp475. marcescens. Jul 28, 2014 · The authors' comparative analyses reveal the core genome of S. 6 , 2096–2110 (2014). isolates were susceptible to tigecycline, by the FDA breakpoints, in all studies, with MIC 90 values of 1–4 mg/L. marcescens is resistant to a wide range of The chromosomes of Serratia marcescens strains SM39 and Db11. 960285. Su L-H, Ou JT, Leu H-S, et al. Agents Chemother. Tucker, Sara E. 2014. Recently, S. marcescens, an in-depth analysis of the population structure and variation is required. marcescens is resistant to a wide range of Colors correspond to hospitals. Serratia spp. marcescens subspecies marcescens strain ATCC 13880 and multidrug-resistant isolate Serratia species Highly Resistant Isolate (HRI) were submitted to a prediction pipeline tool to compare efflux system profiles and identify any resistance efflux systems . The present study aimed to further clarify the genetic mechanisms responsible for the antimicrobial resistance of Serratia marcescens (S. Perl Sep 4, 2020 · A promising drug delivery candidate (CS-g-PMDA-CYS-fused gold nanoparticles) for inhibition of multidrug-resistant uropathogenic Serratia marcescens Ping Shi , a Rajendran Amarnath Praphakar , b Sadhasivan Deepa , b Kannan Suganya , c Prashant Gupta , d Riaz Ullah , e Ahmed Bari , f Marudhamuthu Murugan , c and Mariappan Rajan b May 18, 2011 · ABSTRACT Serratia marcescens gained resistance to both biocides and antibiotics on expressing the SdeAB efflux pump, following exposure to increasingly higher concentrations of a biocide (H. The only antibiotic that has been proven to be effective against S. marcescens have become a global public health issue. marcescens CAV1492). Using the drug-hyp … Mar 8, 2023 · INTRODUCTION. 1101 - 1109 , 10. - "Recent independent emergence of multiple multidrug-resistant Serratia marcescens clones within the United Kingdom and Ireland" Sep 1, 2003 · SdeXY is the first RND-type multidrug efflux pump to be characterized in multidrug-resistant S. , are significantly less likely to overexpress ampC based on both in vitro analysis 164,165 and clinical reports 150,159,166. marcescens bacteria isolated from various clinical specimens according to body regions and clinics and to evaluate for enzyme production rates associated with antibiotic resistance of these isolates. Feb 9, 2023 · Background: Serratia marcescens (SM) is a Gram-negative pathogen discovered by Italian pharmacist, Bizio, in 1819. Here we report an IncHI2/2A plasmid carrying blaIMP-26 and mcr-9 in multidrug-resistant Serratia Oct 18, 2022 · Serratia marcescens , a Gram-negative bacterium, is one of the known disease-causing pathogens. Oct 1, 2018 · The role of the Serratia marcescens SdeAB multidrug efflux pump and TolC homologue in fluoroquinolone resistance studied via gene-knockout mutagenesis Article Full-text available Objectives: Serratia marcescens, an important cause of nosocomial infections, shows intrinsic resistance to a wide variety of antimicrobial agents (multidrug resistance). [Google Scholar] 99. marcescens have evolved to become a versatile and opportunistic pathogen. , J Clin Microbiol 55:2334-2347; Dante et al. , and Escherichia coli. , and Acinetobacter are available on the Healthcare-Associated Infection (HAI) website. (S. Serratia marcescens is an important agent in hospital infections. The broad antimicrobial spectrum of aminoglycosides and their synergistic antimicrobial effect in association with other drugs (such as β-lactams and fluoroquinolones) suggest the possible use of these antibiotics as a therapy for life Aug 1, 2003 · SdeXY is the first RND-type multidrug efflux pump to be characterized inMultidrug-resistant S. (C) A histogram of pairwise SNP distances between all 205 isolates. Reference Ferreira, Rezende and Damas 1, Reference Cilli, Nazli-Zeka and Arda 2 S. strains exhibiting multidrug-resistance were analyzed with high-throughput rna sequencing to identify variations at the transcriptome level. marcescens is resistant to a wide range of antibiotics, including penicillin, cephalosporin, tetracycline, macrolide, nitrofurantoin, and colistin. Background: Serratia marcescens (SM) is a Gram-negative pathogen discovered by Italian pharmacist, Bizio, in 1819. J Antimicrob Chemother. Jun 26, 2020 · A promising drug delivery candidate (CS-g-PMDA-CYS-fused gold nanoparticles) for inhibition of multidrug-resistant uropathogenic Serratia marcescens Ping Shi a Management Office of Drug Clinical Trial Research, Affiliated Hospital of Qingdao University, Qingdao, Shandong Background: Serratia marcescens (S. marcescens strains were screened, followed by functional enrichment An outbreak of urinary tract infections caused by multidrug-resistant Serratia marcescens lasted for 12 months and was found to be related to urologic instrumentation. Serratia marcescens is an important nosocomial pathogen that can cause an array of infections, most Oct 18, 2022 · Serratia marcescens, a Gram-negative bacterium, is one of the known disease-causing pathogens. 1093/gbe/evu160 Oct 20, 2021 · Hornsey M, Ellington MJ, Doumith M, Hudson S, Livermore DM, Woodford N. May 4, 2023 · Antibiotic therapy is the main method of treating infections caused by S. 5%). Feb 5, 2022 · Although the S. marcescens strains; a clinical isolate that showed a high level multidrug resistance (strain SM39) and a spontaneous streptomycin-resistant mutant derived from the strain Db10 originally isolated from a moribund fly (strain Db11). marcescens antibiotic resistance is active efflux. Genome Res 26:1101–1109. ) Not reported because Serratia is not reportable in jurisdiction by laboratories or healthcare providers We report here the draft genome sequence of Serratia marcescens ML2637, isolated from a South African pediatric patient in the intensive care unit with peritoneal cancer. Jan 1, 2019 · Recent independent emergence of multiple multidrug-resistant Serratia marcescens clones within the United Kingdom and Ireland Genome Res. Endogenous Serratia marcescens Endophthalmitis with Dark Hypopyon. To ascertain the substrate specificity of the S. 1166/jnn. These strains are often resistant to last-resort antibiotics, such as carbapenems, which are typically reserved for severe infections. 1. The occurrence of multidrug-resistant Serratia marcescens strains represents a serious public health threat. Genome evolution and plasticity of Serratia marcescens, an important multidrug-resistant nosocomial pathogen. sdeCDE knockout strains showed no change in antibiotic susceptibility in comparison with the parental strains Physical examination revealed multifocal pain on bone palpation and fever. For instance, the chromosomal ampC gene encoding for the AmpC-type β-lactamases is typically present Jan 5, 2023 · S. Baptista PV, McCusker MP, Carvalho A, Ferreira DA, Mohan NM, Martins M, Fernandes AR. All showed fairly high resistance to many antimicrobial agents tested including norfloxacin, streptomycin, ampicillin, erythromycin, tetracycline, chloramphenicol, and antimicrobial dyes. 2022. Keywords: Serratia marcescens, reverse vaccinology, multidrug resistance, computational approaches, subtractive proteomics. Multidrug efflux pumps are often involved in the multidrug resistance in many bacteria. Nov 14, 2022 · In this study, the genomes of S. Three drug‑susceptible S. Multidrug-Resistant Serratia marcescens bacteriuria related to urologic instrumentation. The aim of this study was to examine the antimicrobial resistance profiles of S. Multidrug-resistant Multi-drug antibiotic resistance of Serratia (S. marcescens population harbored 3 core resistance genes (beta-lactamase resistance gene bla SRT-2, aminoglycoside resistance gene AAC(6')-lc, and multidrug resistance genes CRP), which were shared by > 99% of the S. Feb 5, 2014 · For other organisms with chromosomally mediated inducible AmpC β-lactamase resistance (eg, Citrobacter species, Serratia marcescens), we suggest following in vitro susceptibilities, with the exception of central nervous system infections. Jul 25, 2023 · Serratia marcescens is an opportunistic nosocomial pathogen, and recent reports have highlighted the rapid increase in multidrug resistance in this organism. 4 However, the therapeutic effectiveness has been attenuated by emerging resistant strains. The genome comprised 5,718,350 bp, with a 59. [Google Scholar] 51. OBJECTIVE Serratia marcescens is a well-established as a nosocomial pathogen, resulting in considerable morbidity and mortality in Here, we demonstrate that the production of prodigiosin by newly isolated S. The pangenome of S. The lines connect identical tips of the two trees. marcescens SdeCDE efflux pump, we constructed pump gene deletion mutants. marcescens infections outbreak in our tertiary-level NICU and the application of molecular typing using repetitive element . The purpose of this research was to investigate antibiotic resistance in Serratia marcescens isolates from clinical samples over seven years at the University Hospital “San Giovanni di Dio e Ruggi d’Aragona Jul 28, 2014 · S. Purpose: Serratia marcescens owns different virulence factors that contribute to Jul 18, 2016 · The expansion of these multidrug-resistant clones suggests that the treatment of S. marcescens Strains, Culture Media, and Growth Conditions. The emergence of multidrug-resistant strains is an increasing danger to public health. The distances are based on the core genome alignment. Recent independent emergence of multiple multidrug-resistant Serratia marcescens clones within the United Kingdom and Ireland. The core genome -made of loci present in >95% of genomes- contained 3155 genes (16. We report the investigation and control of an outbreak of multidrug-resistant (MDR) S. The hospital environment can play an essential role in the transmission of multidrug resistant pathogens, including Serratia marcescens which is able to survive in most of them. 1 The extensive use and misuse of antibiotics since their discovery has resulted in a significant increase in the emergence and spread of multidrug-resistant (MDR) bacteria, and there is increasing morbidity and mortality caused by their invasive infection. Jul 28, 2014 · Serratia marcescens is an important nosocomial pathogen that can cause an array of infections, most notably of the urinary tract and bloodstream. High levels of antibiotic resistance across Serratia species are a consequence of the combined activity of intrinsic, acquired, and adaptive resistance elements. Furthermore, this bacterium is also a multi-drug resistant pathogen exhibiting Extended-Spectrum Beta-Lactamases (ESBL) activity. Serratia marcescens causes healthcare-associated infections and significant morbidity and mortality in neonatal intensive care units (NICUs). marcescens) using RNA sequencing. 1% G+C content. Histopathologic evaluation of bone biopsies showed severe chronic pyogranulomatous osteomyelitis and multidrug-resistant Serratia marcescens was cultured. Citation: Damas MSF, Mazur FG, Freire CCM, Cunha AF and Pranchevicius M-CS (2022) A Systematic Immuno-Informatic Approach to Design a Multiepitope-Based Vaccine Against Emerging Multiple Drug Resistant Serratia marcescens Mar 27, 2024 · In healthcare settings, Serratia marcescens is known to colonise and cause pathogenic illnesses. marcescens strains isolated during 1 year from patients of various wards of the Institute of Transplantology. South Med J 1984;77:173–7. Cosgrove, Tracy Ross, Edward Lawson, Karen C. 2021, 52, 1341–1345. 2010;65(3):479–482. , Antimicrob. Therefore, the purpose of this study was to investigate the antibiotic susceptibility and plasmid profiles of multidrug-resistant (MDR) uropathogenic Serratia marcescens. 53:5230–5235, 2009). doi: 10. Apart from acquired drug resistance, treatment options are additionally hampered by intrinsic, chromosomal-encoded resistance. The nine multi-drug resistant Serratia isolates also possessed a Ser-83-Ile mutation Aug 1, 2003 · Objectives: Serratia marcescens, an important cause of nosocomial infections, shows intrinsic resistance to a wide variety of antimicrobial agents (multidrug resistance). 2014;14(7):4745–4756. Naturally, it is found in many environmental niches, and is capable of infecting plants and animals. aureus, with this pathogen’s viability decreasing 6-log over 24 h. J Nanosci Nanotechnol. It is resistant to ampicillin, macrolides, cephalosporins, cefotaxime, and ceftazidime. The aim of this paper was to compare the resistance patterns of S. differentially expressed genes (deGs) between the parental strain and the multidrug-resistant S. Jun 15, 2024 · Download Citation | Copper Nanoparticles Enhance Bactericidal Activity of 70% Ethanol Against Multidrug-Resistant Serratia marcescens. essential oil (CCeo) alone and in combination with antibiotics against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens. The semen samples extended in Mar 19, 2019 · We investigated the role of the resistance-nodulation-cell division superfamily (RND) efflux system on intrinsic multidrug resistance in Serratia marcescens. (2009) Maseda H, Hashida Y, Konaka R, Shirai A, Kourai H. In light of the inevitable spread of multi-drug resistance among clinically relevant bacterial species, new ways of antibacterial therapy are desperately needed. This study reports the anti-pathogenic activity of Punica granatum peel extract (PGPE) against a multi-drug resistant, beta-lactamase producing member of this family i. Three challenging cases of infections by multidrug-resistant Serratia marcescens in patients admitted to intensive care units Kesia Esther da Silva1 & Luana Rossato1 & Sérgio Jorge2 & Natasha Rodrigues de Oliveira2 & Frederico Schmitt Kremer2 & Vinícius Farias Campos2 & Luciano da Silva Pinto 2 & Odir Antonio Dellagostin2 & Simone Simionatto1,3 May 10, 2018 · Other plasmids harboring heavy metal resistance are also present in some of the Serratia spp. 2-Mb chromosome and a 26. 9527. Pan-genome analysis of Serratia The role of nanotechnology in combating multi-drug resistant bacteria. genomes (mercury resistance genes in plasmid pCAV1492-73 and pSMC1from the nosocomial strains S. Evol. The emergence and spread of multidrug-resistant strai … Abstract. Oct 1, 2021 · Carbapenem-resistant Enterobacterales (CRE) has become a major therapeutic concern in clinical settings, and carbapenemase genes have been widely reported in various bacteria. 1980). Serratia species are gram-negative bacilli of the Enterobacterales order, although they are not a common component of healthy human fecal flora. marcescens is resistant to a wide range of Jul 23, 2020 · Multidrug resistance prompts the search for new sources of antibiotics with new targets at bacteria cell. Jan 5, 2023 · S. marcescens RH10 correlates with its antibacterial activity against a multidrug-resistant strain of S. ABSTRACT –Serratia marcescens has been recognized as an opportunistic nosocomial pathogen. Infect Control Hosp Epidemiol 2006; 27: 774-777. There were 5,594 predicted Jun 28, 2022 · The spread of multidrug-resistant enterobacteria strains has posed a significant concern in public health, especially when the strain harbors metallo-beta-lactamase (MBL)-encoding and mobilized colistin resistance (<i>mcr</i>) genes as such genetic components potentially mediate multidrug resistance … Mar 15, 2022 · Abstract. , 26 ( 2016 ) , pp. marcescens CAV1492 and S. Aug 16, 2022 · Serratia marcescens (S. The numbers next to edges denote pairwise SNP distance between isolates. The antimicrobial susceptibility of the strains was determined by Vitek® 2 and cially multidrug resistance, is required to control multidrug resistant bacteria and to treat patients infected with mul-tidrug-resistant bacteria successfully. Until late in the 20th century, S. Keywords: Serratia marcescens, intrinsic antibiotic resistance, bacteriophage, synergy. Mar 17, 2022 · The bacterium Serratia marcescens can cause opportunistic infections in humans and in animals. ABSTRACT Objectives: Genetic elements such as plasmids play a role in spreading multi-antibiotic resistance, a global threat. Dec 4, 2024 · The genus Serratia has a wide distribution spanning soil, water, and host-associated environments and includes some members known to function as opportunistic pathogens in humans and other organisms (1, 2). marcescens was considered a nonpathogenic saprophytic organism. Serratia marcescens is a ubiquitous bacterium from order Enterobacterales displaying a high genetic plasticity that allows it to adapt and persist in Jul 1, 2020 · During the antibiotic crisis, bacteriophages (briefly phages) are increasingly considered as potential antimicrobial pillars for the treatment of infectious diseases. . The purpose here is to report three cases of carbapenem-resistant S. To design effective means to control the dissemination of S. marcescens built from 45 genome assemblies comprised a total of 19469 genes. marcescens and define the potential metabolic capacity, virulence, and multidrug resistance of this species, and show a remarkable intraspecies genetic diversity, both at the sequence level and with regards genome flexibility. 2 Outbreak of multidrug-resistant Serratia marcescens infection in a neonatal intensive care unit Lisa L. Introduction. 10. Serratia marcescens, a member of the Enterobacteriaceae family, is a Gram-negative bacterium Dec 14, 2023 · The Serratia marcescens is a Gram-negative bacterium from the Enterobacteriaceae family. Nano-strategies to fight multidrug resistant bacteria—“A Battle of the Titans”. Serratia marcescens is a Gram-negative bacillus that naturally resides in the soil and water and produces a red pigment at room temperature. The aim of this study is to elucidate the effect of a biocide on the emergence of biocide- and antibiotic-resistant Jan 5, 2023 · This review will discuss recent advances in the understanding of mechanisms guiding resistance in this opportunistic pathogen, S. In veterinary settings, the diversity, reservoirs and modes of transmission of this pathogen are poorly understood. marcescens strains (named MYQT1, MYQT2, and MYQT3) and three multidrug‑resistant S. Apr 8, 2021 · The occurrence of multidrug-resistant Serratia marcescens strains represents a serious public health threat. We describe the control of a multi-clonal S. marcescens infections with unfavorable clinical outcomes and provide a molecular description of the antibiotic resistance … The expansion of these multi-drug-resistant clones suggests that the treatment of S. , 2016; Du et al Carbapenem-resistant Enterobacteriaceae are a major class of bacterial pathogens globally, but studies have focused on the organisms most commonly associated with clinical infections in the United States: Klebsiella spp. This bacterium is highly associated with infections in healthcare settings and even leads Keywords: Serratia marcescens, multidrug resistance, mcr-9, bla IMP-26, megaplasmids IMP-26, evolutionary pathway. marcescens strain and marcescensS. aureus, with this pathogen's viability decreasing 6-log over 24 h. marcescens isolated from UTI with high antibiotic resistance capacity, necessitates for further studies on virulence factors using modern molecular techniques to develop novel antimicrobials utilizing strategies which target pathogenic bacteria's virulence genes. The nine multi-drug resistant Serratia isolates also possessed a Ser-83-Ile mutation in GyrA conferring fluoroquinolone resistance, and carried a large IncHI2 conjugative plasmid encoding antimicrobial and Oct 17, 2022 · Citation: Naveed M, Mughal MS, Jabeen K, Aziz T, Naz S, Nazir N, Shahzad M, Alharbi M, Alshammari A and Sadhu SS (2022) Evaluation of the whole proteome to design a novel mRNA-based vaccine against multidrug-resistant Serratia marcescens. marcescens strains, which pose threats to public health, prompts actions to control their growth and dissemination. Maseda et al. , Genome Biol Evol 6:2096-2110, 2014; Teresa et al. Serratia marcescens is an opportunistic nosocomial pathogen, and recent reports have highlighted the rapid increase in multidrug resistance in this organism. A study was undertaken to characterize the multidrug efflux pumps in S. Jan 2, 2015 · Background. May 30, 2024 · Introduction: Serratia marcescens is an opportunistic pathogen found ubiquitously in the environment and associated with a wide range of nosocomial infections. Front. marcescens (CRSM). marcescens strains (named MYQT4, MYQT5, and MYQT6) were isolated from six different patients and subjected to Jun 28, 2022 · The spread of multidrug-resistant enterobacteria strains has posed a significant concern in public health, especially when the strain harbors metallo-beta-lactamase (MBL)-encoding and mobilized colistin resistance (mcr) genes as such genetic components potentially mediate multidrug resistance. Genome Biol. marcescens is particularly concerning. [Supplemental material is available for this article. Microbiol. ) oxytoca in boar semen is an emerging threat to pig reproduction and the environment. Infect Control Hosp Epidemiol. Particularly, outbreaks produced by multidrug-resistant isolates of this species, which is already naturally resistant to several antibiotics, including colistin, are usually described with high rates of fatal outcomes throughout the world. Serratia marcescens observed in hospitals often presents different resistance mechanisms; however, they are rarely extensively drug-resistant (XDR). Horcajada JP, Martínez JA, Alcón A, Marco F, De Lazzari E, de Matos A, Zaragoza M, Sallés M, Zavala E, Mensa J. This multidrug-resistant bacterium has been a cause of concern for hospitals and healthcare facilities due to its ability to spread rapidly and cause outbr Six clinically isolated strains of Serratia marcescens were tested for their drug resistance. marcescens subsp. marcescens strains … Horcajada JP, Martínez JA, Alcón A, Marco F, De Lazzari E, de Matos A, Zaragoza M, Sallés M, Zavala E, Mensa J. marcescens, and shows reduced susceptibility to several antimicrobial agents including erythromycin, tetracycline, norfloxacin and rhodamine 6G. 205245. 116 View in Scopus Google Scholar Apr 26, 2008 · Serratia marcescens is an important nosocomial agent having high antibiotic resistance. isolated from dogs, cats, horses, a bird and a rabbit examined at an Australian veterinary hospital between 2008 and 2019 were Jan 10, 2019 · Genome evolution and plasticity of Serratia marcescens, an important multidrug-resistant nosocomial pathogen. The emergence of multidrug-resistant S. Maragakis, Amy Winkler, Margaret G. marcescens) is an environmental bacterium that causes infections with high morbidity and mortality. e. 5 Meanwhile, the common multidrug-resistant nature of S. Abstract. marcescens) is a rising contributor to spinal implant infections (Iguchi et al. 1, 2 A report from the United States in 2014–2017 described Serratia marcescens Apr 8, 2021 · The occurrence of multidrug-resistant Serratia marcescens strains represents a serious public health threat. marcescens is gentamicin. Although previously considered non-pathogenic, this species has emerged as a prominent opportunistic pathogen found in nosocomial outbreaks in neonatal intensive care Units (NICUs), intensive care units (ICUs) and other hospital units over S. [QxMD MEDLINE Link]. May 5, 2023 · Multi-drug antibiotic resistance of Serratia (S. marcescens) is associated with nosocomial infections with significant morbidity and mortality in the neonatal intensive care units (NICU). Its complete genome sequence was determined using PacBio RS II SMRT technology, consisting of a 5. The emergence of multidrug-resistant strains is an increasing danger to public health. OBJECTIVES Serratia marcescens, an important cause of nosocomial infections, shows intrinsic resistance to a wide variety of antimicrobial agents (multidrug multidrug-resistant Serratia marcescens Muhammad Naveed1*, Muhammad Saad Mughal1, Khizra Jabeen1, Tariq Aziz2*, Sumaira Naz3, Nausheen Nazir3, Muhammad Shahzad4, Metab Alharbi5, Abdulrahman Alshammari5 and Satya Sai Sadhu6 1Department of Biotechnology, Faculty of Science and Technology, University of Central Punjab, Echols RM, Palmer DL, King RM, et al. Keywords: Serratia marcescens, outbreaks, NICUs. The aim of this study was to investigate an outbreak of Serratia marcescens at the Orthopaedic Clinic of the Clinical Center University of Sarajevo. - "Recent independent emergence of multiple multidrug-resistant Serratia marcescens clones within the United Kingdom and Ireland" Jan 21, 2016 · Serratia marcescens SmUNAM836 is a multidrug-resistant clinical strain isolated in Mexico City from a patient with chronic obstructive pulmonary disease. | Copper nanoparticles (CuNPs) were synthesized by an Jun 6, 2006 · A review about the molecular traits evolved in the pathogenic processes mediated by Serratia and its mechanism of resistance to drugs and plasmides that confers multi-drug resistance are presented. Most isolates from patients in burn center or adult ICU. As the genetic determinants can be transmitted easily from one species to another, rigorous implementation of infection control measures is of utmost importance in the hospital setting [4,6]. 6 Indeed, lines of studies revealed an alarming Serratia marcescens has been tracked by the Microbiology supervisor as a MDR GNB. According to the literature, S. marcescens complicates the treatment of its infections. 2006 Jul. More recent some Serratia isolates show resistance to all antibiotics except imipenem. Serratia marcescens causes health care-associated infections with important morbidity and mortality. Jun 1, 2008 · Serratia marcescens is the most important opportunistic human pathogen among Serratia species, often multidrug resistant and involved in outbreaks of HAIs in neonatal intensive care units (NICU Jul 17, 2024 · ARGs associated with the critical nosocomial pathogen Serratia marcescens persist up to 8–10 months of age, representing a long-lasting hospitalization signature. 8, 16, 26, 29, 33, 35, 39, 43–49, 55 We Apr 12, 2024 · The Containment Strategy Guidelines that address novel and targeted MDROs, such as Candida auris and carbapenemase-producing Enterobacterales, Pseudomonas spp. Sep 14, 2009 · Serratia marcescens is an important opportunistic pathogen in hospitals, where quaternary ammonium compounds are often used for disinfection. Serratia marcescens. Received: 02 June 2022; Accepted: 01 August 2022; Background: Antibiotic-resistant members of the family Enterobacteriaceae are among the serious threats to human health globally. ) marcescens and Klebsiella (K. Dec 5, 2024 · We then isolated the transferable plasmids of Serratia marcescens and sequenced them to identify that they indeed carry a number of resistance gene sequence fragments and efflux pump genes, such as multidrug resistance, beta-lactamase, tetracycline resistance, and antibiotic efflux pump membrane transporters (Figure. Serratia marcescens, a member of the Enterobacteriaceae family, is a Gram-negative bacterium responsible for a wide range of nosocomial infections. Only six patients had indwelling bladder catheters. 1101/gr. marcescens infections will become increasingly difficult in the future. Serratia marcescens has the ability to produce inducible AmpC β-lactamase and may even acquire extended Serratia marcescens gained resistance to both biocides and antibiotics on expressing the SdeAB efflux pump, following exposure to increasingly higher concentrations of a biocide (H. marcescens infections are difficult given the limited clinical study data available and concerns about the potential for inducible multidrug resistance. In the early part of the 20 th century, Serratia marcescens was considered a nonpathogenic organism and was used in medical experiments and as a biological warfare test agent []. The medi … Objectives: Serratia marcescens is a neglected opportunistic pathogen of public-health concern, especially due to its antimicrobial resistance features. , Enterobacter spp. One of the leading control strategies which has the potential to be used Jul 28, 2014 · Here, we report and compare the complete genome sequences of two S. We identified eight putative RND multidrug resistance (SMR), (iv) multidrug and toxic compound extrusion (MATE), (v) resistance/nodulation/cell division (RND) superfamily, and (vi) proteobacterial antimicrobial compound efflux (PACE) families operate as chemiosmotic coupling secondary active transporters powered by electrochemical ion gradients (Blanco et al. Journal Genome Biol Evol 6:2096-110 (2014) DOI: 10. Therefore, the discovery of promising compounds to reduce the virulence of pathogens and restore antibiotic activity Dec 13, 2024 · Horcajada JP, Martinez JA, Alcon A, et al. It has been reported that S. We conducted a systematic review of published reports, determined what invasive infections could Apr 3, 2024 · The spread of antibiotic resistance represents a serious worldwide public health issue, underscoring the importance of epidemiology research in determining antimicrobial strategies. marcescens infections with unfavorable clinical outcomes and provide a molecular description of the antibiotic resistance determinants at a genomic level. Braz. To design See full list on antimicrobe. marcescens isolates and likely originated within S. Dashed circles showpotential between-hospital transmissions and the locations of those hospitals on the map. 3, 4 Aug 1, 2016 · This work characterized the population structure and variation, as well as the antimicrobial resistance determinants, of a systematic collection of antimicrobial-resistant S. marcescens strain (UCO-366) recovered from a catheter tip culture of a hospitalised patient in Santiago, Chile, in 2014. Because of the frequency of opportunistic infections in hospital settings, the distribution and evolution of antibiotic resistance in Serratia are of particular concern (e. By causing epigenetic alterations, bacteria can also become resistant Three challenging cases of infections by multidrug-resistant Serratia marcescens in patients admitted to intensive care units. 2002). Mar 22, 2022 · A genomic island encoding a homolog of the Pseudomonas MexCD-OprJ biocide efflux system was detected in the chlorhexidine-tolerant Serratia. We performed bacterial identification by VITEK 2 and MALDI-TOF Serratia marcescens is an important nosocomial pathogen causing various opportunistic infections, such as urinary tract infections, bacteremia and sometimes even hospital outbreaks. The phenotypes and genotypes of Serratia spp. Apr 6, 2023 · There is a high prevalence of virulence genes in S. 2%), the dispensable genome contained 7847 genes (40. The aim of this study is to examine the efficiency of a novel hypothermic preservation method to inhibit the growth of these bacterial species in extended boar semen and to maintain the sperm quality. Article Google Scholar Apr 8, 2021 · Background: Serratia marcescens (SM) is a Gram-negative pathogen discovered by Italian pharmacist, Bizio, in 1819. ] The Gram-negative bacillus Serratia marcescens is a member of the Enterobacteriaceae that resides in environmental soil and water Serratia marcescens is an important nosocomial pathogen that can cause an array of infections, most notably of the urinary tract and bloodstream. Strain SM39 was isolated from a septicemic patient in Japan in 1999 (Nakamura et al. From the outside in, the first circle shows the nucleotide sequence positions (in Mb), and the second circle shows the locations of strain-specific regions of ≥5 kb (purple: prophages and integrative elements; red: others) with an indication of their features and/or encoded Dec 8, 2014 · The acquisition of multidrug resistance in nosocomial pathogens such as Serratia marcescens has been reported in the absence of antibiotic selection pressure. Serratia marcescens typically is a multidrug-resistant organism, perhaps owing to its pervasiveness in the environment and exposure to various antibiotics that have selected for those strains that carry resistance. g. Aug 1, 2008 · We reviewed 22 studies reporting the activity of tigecycline against Serratia spp. The aim of this study is to examine the efficiency of a novel hypothermic preservation method to inhibit the growth of these bacterial species in extended boar semen and to Jan 5, 2023 · Maseda et al. Apr 1, 2003 · Serratia marcescens, an important cause of nosocomial infections, shows intrinsic resistance to a wide variety of antimicrobial agents (multidrug resistance). Radiographs showed mixed lytic-proliferative polyostotic diaphyseal osteopathy of multiple bone segments. (A) Circular maps of the SM39 and Db11 chromosomes. By causin … Dec 13, 2024 · Horcajada JP, Martinez JA, Alcon A, et al. marcescens increasingly adapts to different hospital environments, making it difficult to identify and eliminate the source of an outbreak. 8, 16, 20–22, 26, 28, 29, 33–35, 39, 41–49, 55 More than 90% of the non-MDR Serratia spp. In this review, we will discuss recent advances in the understanding of mechanisms guiding resistance in this opportunistic pathogen. A major mechanism for S. marcescens, as mentioned above, a high diversity of AMR genes Apr 15, 2020 · Antimicrobial resistance (AMR) is a global health challenge that transcends borders yet disproportionally impacts the most vulnerable. Tigecycline resistance in Serratia marcescens associated with up-regulation of the SdeXY-HasF efflux system also active against ciprofloxacin and cefpirome. org Jan 14, 2025 · The emergence of multidrug-resistant strains of S. In this review, we will discuss recent advances in the understanding of Jul 29, 2022 · S. Jul 12, 2024 · In contrast, other organisms historically presumed to be at moderate risk for the development of clinically significant ampC expression, such as Serratia marcescens, Morganella morganii, and Providencia spp. There is a paucity in genomic data for carbapenem-resistant S. The aim of this study is to examine the efficiency of a novel hypothermic Oct 18, 2022 · Serratia marcescens, a Gram-negative bacterium, is one of the known disease-causing pathogens. Available Objective: Serratia marcescens is a well-established as a nosocomial pathogen, resulting in considerable morbidity and mortality in immunocompromised patients. J. The recent emergence and spread of multidrug-resistant (MDR) Apr 21, 2020 · This study reports anti-pathogenic activity of Punica granatum peel extract (PGPE) against a multi-drug resistant, beta-lactamase producing member of this family i. Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. Serratia marcescens is a bacterium of the Enterobacteriaceae family that thrives in damp environments such as Feb 9, 2023 · Background: Serratia marcescens (SM) is a Gram-negative pathogen discovered by Italian pharmacist, Bizio, in 1819. Serratia marcescensis now becoming an important cause of hospital-acquired infections. marcescens isolates recovered from clinical settings are frequently described as multidrug resistant. 1097/00007611-198402000-00010 [Google Scholar] 10. Extended epidemic of nosocomial urinary tract infections caused by Serratia marcescens. Apr 2, 2024 · Moradigaravand D, Boinett CJ, Martin V, Peacock SJ, Parkhill J. 3-kb plasmid, encoding multiple resistance determinants and virulence Jun 1, 2020 · Serratia marcescens is a neglected opportunistic pathogen of public-health concern, especially due to its antimicrobial resistance features. xdg adu qwa pzxvj vkp hurt ytp jqpbd vzf piy

Multidrug resistant serratia marcescens. 53:5230–5235, 2009).